Chicken Fajitas Lettuce Wraps

For a low-carb, lower-calorie twist on fajitas, skip the tortillas in favor of crunchy romaine lettuce. The leaves make for fun handheld “boats” that hold all the delicious fillings so you can enjoy the works—including avocado, salsa and sour cream.

This is an easy meal prep option for lunch or dinner. If you’d like to decrease the calories a bit, swap the sour cream with low-fat Greek yogurt; you’ll decrease the fat and get some extra protein this way.

Active time: 12 minutes | Total time: 32 minutes

Chicken Fajitas Lettuce Wraps

Ingredients

• 1 lb (454g) boneless, skinless chicken breasts, thinly sliced
• 1 tbsp canola oil, divided
• 1 tsp ground cumin
• 1 tsp smoked paprika
• 1 tsp garlic powder
• 1 tsp kosher salt, divided
• 1 medium red bell pepper, thinly sliced
• 1 medium yellow bell pepper, thinly sliced
• 1 large yellow onion, thinly sliced
• 1 medium avocado, mashed
• 8 romaine lettuce leaves (about 120g)
• 1/2 cup (120g) fresh salsa
• 1/2 cup (120g) low-fat sour cream

Directions

Place a large rimmed sheet pan in the oven. Preheat the oven to 450°F (230ºC), leaving the pan in the oven as it heats.

In a medium bowl, toss the chicken with 1.5 tsp oil. In a small bowl, combine cumin, paprika, garlic powder and 1/2 tsp salt. Sprinkle spice mixture over the chicken; toss well to coat. In a large bowl, combine the bell peppers and onion. Drizzle with remaining 1.5 tsp oil and sprinkle with 1/4 tsp salt; toss to coat. Arrange chicken and vegetables on the preheated pan, spreading in an even layer. Bake until chicken is cooked through and vegetables are crisp-tender, 18–20 min, stirring after 10 min.

Meanwhile, stir the remaining 1/4 tsp salt into the mashed avocado. Spoon about 1/2 cup chicken mixture into each lettuce leaf; top each with about 2 tbsp avocado, 1 tbsp salsa and 1 tbsp sour cream.

Serves: 4 | Serving Size: 2 fajitas

Nutrition (per serving): Calories: 356; Total Fat: 19g; Saturated Fat: 4g; Monounsaturated Fat: 10g; Polyunsaturated Fat: 3g; Cholesterol: 93mg; Sodium: 879mg; Carbohydrate: 17g; Dietary Fiber: 5g; Sugar: 5g; Protein: 29g

Nutrition Bonus: Potassium: 1005mg; Iron: 10%; Vitamin A: 10%; Vitamin C: 230%; Calcium: 9%

Originally published October 29, 2020; Updated February 2026

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